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Target
Caspase-3
Ligand
BDBM76667
Substrate
n/a
Meas. Tech.
Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay
IC50
2680±n/a nM
Citation
 PubChem, PC Dose Response confirmation of inhibitors of Sentrin-specific proteases (SENPs) using a Caspase-3 Selectivity assay PubChem Bioassay (2010)[AID] 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM76667
Synonyms:
MLS001210350 | N-[4-(2-methoxyphenyl)-1-piperazinyl]-1-(4-nitrophenyl)methanimine | N-[4-(2-methoxyphenyl)piperazin-1-yl]-1-(4-nitrophenyl)methanimine | SMR000516307 | [4-(2-Methoxy-phenyl)-piperazin-1-yl]-(4-nitro-benzylidene)-amine | [4-(2-methoxyphenyl)piperazino]-(4-nitrobenzylidene)amine | cid_727369
Type:
Small organic molecule
Emp. Form.:
C18H20N4O3
Mol. Mass.:
340.3764
SMILES:
COc1ccccc1N1CCN(CC1)\N=C\c1ccc(cc1)[N+]([O-])=O
Structure:
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