Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM66649
Substrate
n/a
Meas. Tech.
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD
IC50
>118481±n/a nM
Citation
 PubChem, PC Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2010)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM66649
Synonyms:
2-(3-thienyl)-3-hydroxy-4(1H)-quinolinone-7-carboxylic acid N-propylamide | 3-hydroxy-4-keto-N-propyl-2-(3-thienyl)-1H-quinoline-7-carboxamide | 3-hydroxy-4-oxo-N-propyl-2-(3-thiophenyl)-1H-quinoline-7-carboxamide | 3-hydroxy-4-oxo-N-propyl-2-thiophen-3-yl-1H-quinoline-7-carboxamide | 3-oxidanyl-4-oxidanylidene-N-propyl-2-thiophen-3-yl-1H-quinoline-7-carboxamide | MLS000888969 | SMR000453636 | cid_16745872
Type:
Small organic molecule
Emp. Form.:
C17H16N2O3S
Mol. Mass.:
328.386
SMILES:
CCCNC(=O)c1ccc2c(O)c(O)c(nc2c1)-c1ccsc1
Structure:
Search PDB for entries with ligand similarity: