Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM65175
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
8500±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM65175
Synonyms:
1-[(2,4-dichlorobenzoyl)amino]-3-[3-(trifluoromethyl)phenyl]thiourea | 1-[(2,4-dichlorophenyl)carbonylamino]-3-[3-(trifluoromethyl)phenyl]thiourea | 1-[[(2,4-dichlorophenyl)-oxomethyl]amino]-3-[3-(trifluoromethyl)phenyl]thiourea | MLS000588859 | SMR000212491 | cid_3729816
Type:
Small organic molecule
Emp. Form.:
C15H10Cl2F3N3OS
Mol. Mass.:
408.226
SMILES:
FC(F)(F)c1cccc(NC(=S)NNC(=O)c2ccc(Cl)cc2Cl)c1
Structure:
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