Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78421
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
7090±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78421
Synonyms:
1-(5-chloranyl-2-methoxy-phenyl)-3-[2-(4-fluorophenyl)ethyl]thiourea | 1-(5-chloro-2-methoxy-phenyl)-3-[2-(4-fluorophenyl)ethyl]thiourea | 1-(5-chloro-2-methoxyphenyl)-3-[2-(4-fluorophenyl)ethyl]thiourea | MLS001224330 | SMR000678476 | cid_17297684
Type:
Small organic molecule
Emp. Form.:
C16H16ClFN2OS
Mol. Mass.:
338.827
SMILES:
COc1ccc(Cl)cc1NC(=S)NCCc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: