Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM33191
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
13800±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM33191
Synonyms:
4-[(4-chloro-5-dithiazolylidene)amino]benzoic acid ethyl ester | 4-[(4-chlorodithiazol-5-ylidene)amino]benzoic acid ethyl ester | MLS000763689 | SMR000334029 | cid_2769040 | ethyl 4-[(4-chloranyl-1,2,3-dithiazol-5-ylidene)amino]benzoate | ethyl 4-[(4-chloro-5H-1,2,3-dithiazol-5-yliden)amino]benzenecarboxylate | ethyl 4-[(4-chlorodithiazol-5-ylidene)amino]benzoate
Type:
Small organic molecule
Emp. Form.:
C11H9ClN2O2S2
Mol. Mass.:
300.784
SMILES:
CCOC(=O)c1ccc(cc1)\N=c1\ssnc1Cl
Structure:
