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Target
Cysteine protease ATG4B
Ligand
BDBM77907
Substrate
n/a
Meas. Tech.
Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B.
IC50
3350±n/a nM
Citation
 PubChem, PC Dose response confirmation of the uHTS fluorescent assay for identification of inhibitors of ATG4B. PubChem Bioassay (2011)[AID] 
Target
Name:
Cysteine protease ATG4B
Synonyms:
APG4B | ATG4B | ATG4B_HUMAN | AUTL1 | KIAA0943 | cysteine protease ATG4B isoform a | hck
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44279.79
Organism:
Homo sapiens (Human)
Description:
gi_47132611
Residue:
393
Sequence:
MDAATLTYDTLRFAEFEDFPETSEPVWILGRKYSIFTEKDEILSDVASRLWFTYRKNFPAIGGTGPTSDTGWGCMLRCGQMIFAQALVCRHLGRDWRWTQRKRQPDSYFSVLNAFIDRKDSYYSIHQIAQMGVGEGKSIGQWYGPNTVAQVLKKLAVFDTWSSLAVHIAMDNTVVMEEIRRLCRTSVPCAGATAFPADSDRHCNGFPAGAEVTNRPSPWRPLVLLIPLRLGLTDINEAYVETLKHCFMMPQSLGVIGGKPNSAHYFIGYVGEELIYLDPHTTQPAVEPTDGCFIPDESFHCQHPPCRMSIAELDPSIAVGFFCKTEDDFNDWCQQVKKLSLLGGALPMFELVELQPSHLACPDVLNLSLDSSDVERLERFFDSEDEDFEILSL
  
Inhibitor
Name:
BDBM77907
Synonyms:
MLS001224379 | N-[(6-chloranyl-4-oxidanylidene-chromen-3-yl)methylideneamino]-3-methoxy-4-oxidanyl-benzamide | N-[(6-chloro-4-keto-chromen-3-yl)methyleneamino]-4-hydroxy-3-methoxy-benzamide | N-[(6-chloro-4-oxo-1-benzopyran-3-yl)methylideneamino]-4-hydroxy-3-methoxybenzamide | N-[(6-chloro-4-oxochromen-3-yl)methylideneamino]-4-hydroxy-3-methoxybenzamide | SMR000678837 | cid_24818506
Type:
Small organic molecule
Emp. Form.:
C18H13ClN2O5
Mol. Mass.:
372.759
SMILES:
COc1cc(ccc1O)C(=O)NN=Cc1coc2ccc(Cl)cc2c1=O
Structure:
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