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Target
Protein kinase C alpha type
Ligand
BDBM3016
Substrate
Protamine Sulfate
Meas. Tech.
Kinase Inhibition Assay
IC50
>1000±n/a nM
Citation
 Traxler, P; Bold, G; Frei, J; Lang, M; Lydon, N; Mett, H; Buchdunger, E; Meyer, T; Mueller, M; Furet, P Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines. J Med Chem 40:3601-16 (1997) [PubMed]  Article 
Target
Name:
Protein kinase C alpha type
Synonyms:
KPCA_BOVIN | PKC-alpha | PRKCA | Protein Kinase C, alpha | Protein kinase C alpha
Type:
Enzyme
Mol. Mass.:
76842.76
Organism:
Bos taurus (bovine)
Description:
n/a
Residue:
672
Sequence:
MADVFPAAEPAAPQDVANRFARKGALRQKNVHEVKNHRFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVTFSCPGADKGPDTDDPRSKHKFKIHTYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVINVPSLCGMDHTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLNPRWDESFTFKLKPSDKDRRLSEEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNVELRQKFEKAKLGPAGNKVISPSEDRRQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMMDGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPGKRLGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQSAV
  
Inhibitor
Name:
BDBM3016
Synonyms:
3-((4-Aminophenyl)amino)-4-((3-chlorophenyl)amino)-1H-pyrazolo[3,4-d]pyrimidine | 3-N-(4-aminophenyl)-4-N-(3-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidine-3,4-diamine | 4-(Phenylamino)pyrazolo[3,4-d]pyrimidine deriv. 17
Type:
Small organic molecule
Emp. Form.:
C17H14ClN7
Mol. Mass.:
351.793
SMILES:
Nc1ccc(Nc2[nH]nc3ncnc(Nc4cccc(Cl)c4)c23)cc1
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
Protamine Sulfate
Synonyms:
n/a
Type:
Other Protein Type
Mol. Mass.:
358.43
Organism:
n/a
Description:
A purified mixture of simple protein obtained from the sperm or testes of suitable species of fish.
Residue:
3
Sequence:
NA