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Target
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Ligand
BDBM80556
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay
IC50
5323±233 nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay PubChem Bioassay (2011)[AID] 
Target
Name:
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1
Synonyms:
CTDS1_HUMAN | CTDSP1 | NIF3 | NLIIF | SCP1 | carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
29199.89
Organism:
Homo sapiens (Human)
Description:
gi_10864009
Residue:
261
Sequence:
MDSSAVITQISKEEARGPLRGKGDQKSAASQKPRSRGILHSLFCCVCRDDGEALPAHSGAPLLVEENGAIPKQTPVQYLLPEAKAQDSDKICVVIDLDETLVHSSFKPVNNADFIIPVEIDGVVHQVYVLKRPHVDEFLQRMGELFECVLFTASLAKYADPVADLLDKWGAFRARLFRESCVFHRGNYVKDLSRLGRDLRRVLILDNSPASYVFHPDNAVPVASWFDNMSDTELHDLLPFFEQLSRVDDVYSVLRQPRPGS
  
Inhibitor
Name:
BDBM80556
Synonyms:
4-[[4-[(Z)-2-cyano-3-oxidanylidene-3-phenylazanyl-prop-1-enyl]phenoxy]methyl]benzoic acid | 4-[[4-[(Z)-3-anilino-2-cyano-3-keto-prop-1-enyl]phenoxy]methyl]benzoic acid | 4-[[4-[(Z)-3-anilino-2-cyano-3-oxoprop-1-enyl]phenoxy]methyl]benzoic acid | MLS001173501 | SMR000538783 | cid_1924058
Type:
Small organic molecule
Emp. Form.:
C24H18N2O4
Mol. Mass.:
398.4107
SMILES:
OC(=O)c1ccc(COc2ccc(\C=C(\C#N)C(=O)Nc3ccccc3)cc2)cc1
Structure:
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