Reaction Details Report a problem with these data
Target
Phospholipase A2
Ligand
BDBM51714
Substrate
n/a
Meas. Tech.
Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay
IC50
18000±n/a nM
Citation
 PubChem, PC Dose response counterscreen of uHTS hits for ATG4B inhibitors in a Phospholipase A2 assay PubChem Bioassay (2011)[AID] 
Target
Name:
Phospholipase A2
Synonyms:
Group IB phospholipase A2 | PA21B_HUMAN | PLA2 | PLA2A | PLA2G1B | PPLA2 | Phosphatidylcholine 2-acylhydrolase 1B | Phospholipase A2 (PLA2) | Phospholipase A2 group 1B | phospholipase A2 precursor
Type:
Protein
Mol. Mass.:
16364.13
Organism:
Human
Description:
P04054
Residue:
148
Sequence:
MKLLVLAVLLTVAAADSGISPRAVWQFRKMIKCVIPGSDPFLEYNNYGCYCGLGGSGTPVDELDKCCQTHDNCYDQAKKLDSCKFLLDNPYTHTYSYSCSGSAITCSSKNKECEAFICNCDRNAAICFSKAPYNKAHKNLDTKKYCQS
  
Inhibitor
Name:
BDBM51714
Synonyms:
3-[[(E)-(3,5-dibromo-6-keto-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-4-methyl-benzoic acid | 3-[[(E)-(3,5-dibromo-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]-4-methylbenzoic acid | 3-[[(E)-(3,5-dibromo-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-4-methylbenzoic acid | 3-[[(E)-[3,5-bis(bromanyl)-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene]methyl]amino]-4-methyl-benzoic acid | 3-{[(1E)-(3,5-dibromo-2-hydroxyphenyl)methylene]amino}-4-methylbenzoic acid | MLS000586505 | SMR000207884 | cid_6040337
Type:
Small organic molecule
Emp. Form.:
C15H11Br2NO3
Mol. Mass.:
413.061
SMILES:
Cc1ccc(cc1N=Cc1cc(Br)cc(Br)c1O)C(O)=O |w:7.7|
Structure:
Search PDB for entries with ligand similarity: