Reaction Details Report a problem with these data
Target
Endoribonuclease toxin MazF
Ligand
BDBM83542
Substrate
n/a
Meas. Tech.
Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay
EC50
36000±n/a nM
Citation
 PubChem, PC Dose response confirmation uHTS hits for MazEF TA System activators via a fluorescence-based single-stranded RNase assay PubChem Bioassay (2011)[AID] 
Target
Name:
Endoribonuclease toxin MazF
Synonyms:
MAZF_ECOLI | chpA | chpAK | mRNA interferase toxin, antitoxin is MazE | mazF
Type:
Enzyme Catalytic Domain
Mol. Mass.:
12100.43
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130689
Residue:
111
Sequence:
MVSRYVPDMGDLIWVDFDPTKGSEQAGHRPAVVLSPFMYNNKTGMCLCVPCTTQSKGYPFEVVLSGQERDGVALADQVKSIAWRARGATKKGTVAPEELQLIKAKINVLIG
  
Inhibitor
Name:
BDBM83542
Synonyms:
(4Z)-4-{[(2-hydroxy-1H-benzimidazol-6-yl)amino]methylene}-5-methyl-2-(3-methylphenyl)-2,4-dihydro-3H-pyrazol-3-one | 5-[[(E)-[3-methyl-1-(3-methylphenyl)-5-oxidanylidene-pyrazol-4-ylidene]methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(E)-[3-methyl-1-(3-methylphenyl)-5-oxo-4-pyrazolylidene]methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(E)-[3-methyl-1-(3-methylphenyl)-5-oxopyrazol-4-ylidene]methyl]amino]-1,3-dihydrobenzimidazol-2-one | 5-[[(E)-[5-keto-3-methyl-1-(m-tolyl)-2-pyrazolin-4-ylidene]methyl]amino]-1,3-dihydrobenzimidazol-2-one | MLS000585859 | SMR000207640 | cid_12004603
Type:
Small organic molecule
Emp. Form.:
C19H17N5O2
Mol. Mass.:
347.3706
SMILES:
Cc1[nH]n(-c2cccc(C)c2)c(=O)c1C=Nc1ccc2[nH]c(=O)[nH]c2c1 |w:15.17|
Structure:
Search PDB for entries with ligand similarity: