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Target
Glycine hydroxymethyltransferase
Ligand
BDBM50239640
Substrate
n/a
Meas. Tech.
ChEMBL_1666642 (CHEMBL4016438)
IC50
99±n/a nM
Citation
Schwertz, G; Witschel, MC; Rottmann, M; Bonnert, R; Leartsakulpanich, U; Chitnumsub, P; Jaruwat, A; Ittarat, W; Schäfer, A; Aponte, RA; Charman, SA; White, KL; Kundu, A; Sadhukhan, S; Lloyd, M; Freiberg, GM; Srikumaran, M; Siggel, M; Zwyssig, A; Chaiyen, P; Diederich, F Antimalarial Inhibitors Targeting Serine Hydroxymethyltransferase (SHMT) with in Vivo Efficacy and Analysis of their Binding Mode Based on X-ray Cocrystal Structures. J Med Chem 60:4840-4860 (2017) [PubMed] Article
More Info.:
Target
Name:
Glycine hydroxymethyltransferase
Synonyms:
2.1.2.1 | SHMT
Type:
PROTEIN
Mol. Mass.:
49787.58
Organism:
malaria parasite P. falciparum
Description:
ChEMBL_117520
Residue:
442
Sequence:
MFNNDPLQKYDKELFDLLEKEKNRQIETINLIASENLTNTAVRECLGDRISNKYSEGYPHKRYYGGNDYVDKIEELCYKRALEAFNVSEEEWGVNVQPLSGSAANVQALYALVGVKGKIMGMHLCSGGHLTHGFFDEKKKVSITSDLFESKLYKCNSEGYVDMESVRNLALSFQPKVIICGYTSYPRDIDYKGFREICDEVNAYLFADISHISSFVACNLLNNPFTYADVVTTTTHKILRGPRSALIFFNKKRNPGIDQKINSSVFPSFQGGPHNNKIAAVACQLKEVNTPFFKEYTKQVLLNSKALAECLLKRNLDLVTNGTDNHLIVVDLRKYNITGSKLQETCNAINIALNKNTIPSDVDCVSPSGIRIGTPALTTRGCKEKDMEFIADMLLKAILLTDELQQKYGKKLVDFKKGLVNNPKIDELKKEVVQWAKNLPFA