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Target
DCN1-like protein 1
Ligand
BDBM50245154
Substrate
n/a
Meas. Tech.
ChEMBL_1674520 (CHEMBL4024549)
IC50
18±n/a nM
Citation
 Hammill, JT; Bhasin, D; Scott, DC; Min, J; Chen, Y; Lu, Y; Yang, L; Kim, HS; Connelly, MC; Hammill, C; Holbrook, G; Jeffries, C; Singh, B; Schulman, BA; Guy, RK Discovery of an Orally Bioavailable Inhibitor of Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J Med Chem 61:2694-2706 (2018) [PubMed]  Article 
Target
Name:
DCN1-like protein 1
Synonyms:
DCN1 | DCN1-like protein 1 | DCNL1_HUMAN | DCUN1 domain-containing protein 1 | DCUN1D1 | DCUN1L1 | Defective in cullin neddylation protein 1-like protein 1 | RP42 | SCCRO | Squamous cell carcinoma-related oncogene | Synonyms=DCN1
Type:
PROTEIN
Mol. Mass.:
30118.96
Organism:
Homo sapiens
Description:
ChEMBL_117443
Residue:
259
Sequence:
MNKLKSSQKDKVRQFMIFTQSSEKTAVSCLSQNDWKLDVATDNFFQNPELYIRESVKGSLDRKKLEQLYNRYKDPQDENKIGIDGIQQFCDDLALDPASISVLIIAWKFRAATQCEFSKQEFMDGMTELGCDSIEKLKAQIPKMEQELKEPGRFKDFYQFTFNFAKNPGQKGLDLEMAIAYWNLVLNGRFKFLDLWNKFLLEHHKRSIPKDTWNLLLDFSTMIADDMSNYDEEGAWPVLIDDFVEFARPQIAGTKSTTV
  
Inhibitor
Name:
BDBM50245154
Synonyms:
CHEMBL4067795 | US11116757, No. A10
Type:
Small organic molecule
Emp. Form.:
C28H35N3O
Mol. Mass.:
429.597
SMILES:
CCCC(C)N1CCC(CC1)N(Cc1ccccc1)C(=O)Nc1ccc2ccccc2c1
Structure:
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