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Target
Histamine H4 receptor
Ligand
BDBM50259265
Substrate
n/a
Meas. Tech.
ChEMBL_1691274 (CHEMBL4041923)
Ki
19±n/a nM
Citation
 Levoin, N; Labeeuw, O; Billot, X; Calmels, T; Danvy, D; Krief, S; Berrebi-Bertrand, I; Lecomte, JM; Schwartz, JC; Capet, M Discovery of nanomolar ligands with novel scaffolds for the histamine H4 receptor by virtual screening. Eur J Med Chem 125:565-572 (2017) [PubMed]  Article 
Target
Name:
Histamine H4 receptor
Synonyms:
AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44517.02
Organism:
Homo sapiens (Human)
Description:
Binding assays were using CHO cells stably expressing hH4R receptors.
Residue:
390
Sequence:
MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAISDFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAVSYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSFLEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSASTEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARRLAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPLCHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
  
Inhibitor
Name:
BDBM50259265
Synonyms:
CHEMBL4082297
Type:
Small organic molecule
Emp. Form.:
C20H21N3O2
Mol. Mass.:
335.3996
SMILES:
CC(C)(CN=C(c1ccccc1O)c1ccccc1O)c1c[nH]cn1 |(6.49,-2.55,;7.27,-3.89,;8.04,-2.55,;8.61,-4.66,;8.62,-6.2,;9.95,-6.97,;9.96,-8.51,;11.29,-9.27,;11.3,-10.82,;9.96,-11.59,;8.63,-10.82,;8.63,-9.28,;7.3,-8.51,;11.29,-6.19,;11.27,-4.66,;12.6,-3.88,;13.94,-4.65,;13.95,-6.19,;12.62,-6.96,;12.62,-8.5,;5.95,-4.67,;4.54,-4.04,;3.51,-5.19,;4.28,-6.52,;5.79,-6.2,)|
Structure:
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