Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50011229
Substrate
n/a
Meas. Tech.
ChEMBL_195748 (CHEMBL878548)
pH
6.5±n/a
IC50
1.1±n/a nM
Comments
extracted
Citation
Rosenberg, SH; Kleinert, HD; Stein, HH; Martin, DL; Chekal, MA; Cohen, J; Egan, DA; Tricarico, KA; Baker, WR Design of a well-absorbed renin inhibitor. J Med Chem 34:469-71 (1991) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Human
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50011229
Synonyms:
2-Benzyl-N-[1-[1-cyclohexylmethyl-2-(3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(1H-pyrazol-3-yl)-ethyl]-4-morpholin-4-yl-4-oxo-butyramide | CHEMBL342864
Type:
Small organic molecule
Emp. Form.:
C35H50N6O7
Mol. Mass.:
666.8075
SMILES:
CCN1C[C@H](OC1=O)[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](Cc1ccn[nH]1)NC(=O)[C@@H](CC(=O)N1CCOCC1)Cc1ccccc1