Reaction Details Report a problem with these data
Target
Renin
Ligand
BDBM50012757
Substrate
n/a
Meas. Tech.
ChEBML_196104
pH
6±n/a
IC50
350±n/a nM
Comments
extracted
Citation
Dellaria, JF; Maki, RG; Stein, HH; Cohen, J; Whittern, D; Marsh, K; Hoffman, DJ; Plattner, JJ; Perun, TJ New inhibitors of renin that contain novel phosphostatine Leu-Val replacements. J Med Chem 33:534-42 (1990) [PubMed] Article
More Info.:
Target
Name:
Renin
Synonyms:
Angiotensinogenase | REN | RENI_HUMAN
Type:
Enzyme
Mol. Mass.:
45058.99
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
406
Sequence:
MDGWRRMPRWGLLLLLWGSCTFGLPTDTTTFKRIFLKRMPSIRESLKERGVDMARLGPEWSQPMKRLTLGNTTSSVILTNYMDTQYYGEIGIGTPPQTFKVVFDTGSSNVWVPSSKCSRLYTACVYHKLFDASDSSSYKHNGTELTLRYSTGTVSGFLSQDIITVGGITVTQMFGEVTEMPALPFMLAEFDGVVGMGFIEQAIGRVTPIFDNIISQGVLKEDVFSFYYNRDSENSQSLGGQIVLGGSDPQHYEGNFHYINLIKTGVWQIQMKGVSVGSSTLLCEDGCLALVDTGASYISGSTSSIEKLMEALGAKKRLFDYVVKCNEGPTLPDISFHLGGKEYTLTSADYVFQESYSSKKLCTLAIHAMDIPPPTGPTWALGATFIRKFYTEFDRRNNRIGFALAR
Inhibitor
Name:
BDBM50012757
Synonyms:
CHEMBL3143415 | {3-[2-(2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-4-methyl-pentanoylamino]-4-cyclohexyl-2-hydroxy-butyl}-phosphonic acid dimethyl ester
Type:
Small organic molecule
Emp. Form.:
C31H52N3O8P
Mol. Mass.:
625.7336
SMILES:
COP(O)(=O)C[C@H](O)[C@H](CC1CCCCC1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C