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Target
Thymidine kinase
Ligand
BDBM50013093
Substrate
n/a
Meas. Tech.
ChEBML_208031
IC50
8000±n/a nM
Citation
 Hildebrand, C; Sandoli, D; Focher, F; Gambino, J; Ciarrocchi, G; Spadari, S; Wright, G Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases. J Med Chem 33:203-6 (1990) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
KITH_HHV1S | TK | Thymidine kinase | UL23
Type:
PROTEIN
Mol. Mass.:
40883.42
Organism:
HHV-1
Description:
ChEMBL_213
Residue:
376
Sequence:
MASYPGHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRPEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWRVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMIQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM50013093
Synonyms:
2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin-6-one | CHEMBL16026
Type:
Small organic molecule
Emp. Form.:
C14H15N5O
Mol. Mass.:
269.3018
SMILES:
CCc1cc(Nc2nc3nc[nH]c3c(=O)[nH]2)ccc1C
Structure:
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