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Target
Thymidine kinase
Ligand
BDBM50210810
Substrate
n/a
Meas. Tech.
ChEBML_208027
IC50
150±n/a nM
Citation
 Hildebrand, C; Sandoli, D; Focher, F; Gambino, J; Ciarrocchi, G; Spadari, S; Wright, G Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases. J Med Chem 33:203-6 (1990) [PubMed]  Article 
Target
Name:
Thymidine kinase
Synonyms:
KITH_HHV1 | TK | UL23
Type:
PROTEIN
Mol. Mass.:
40902.47
Organism:
HHV-1
Description:
ChEMBL_208027
Residue:
376
Sequence:
MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGMGKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVVMTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMGSMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYGLLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAPNGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPTICDLARTFAREMGEAN
  
Inhibitor
Name:
BDBM50210810
Synonyms:
2-(3-Trifluoromethyl-phenylamino)-1,9-dihydro-purin-6-one | CHEMBL405761 | N2-(3-trifluoromethylphenyl)guanine
Type:
Small organic molecule
Emp. Form.:
C12H8F3N5O
Mol. Mass.:
295.22
SMILES:
FC(F)(F)c1cccc(Nc2nc3nc[nH]c3c(=O)[nH]2)c1
Structure:
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