Reaction Details Report a problem with these data
Target
C-C chemokine receptor type 2
Ligand
BDBM50274434
Substrate
n/a
Meas. Tech.
ChEMBL_1714006 (CHEMBL4124055)
IC50
7833±n/a nM
Citation
 Qin, LH; Wang, ZL; Xie, X; Long, YQ Discovery and synthesis of 6,7,8,9-tetrahydro-5H-pyrido[4,3-c]azepin-5-one-based novel chemotype CCR2 antagonists via scaffold hopping strategy. Bioorg Med Chem 26:3559-3572 (2018) [PubMed]  Article 
Target
Name:
C-C chemokine receptor type 2
Synonyms:
C-C chemokine receptor type 2 (CCR2) | CCR2 | CCR2_HUMAN | CMKBR2 | Chemoattractant Cytokine Receptor 2 (CCR2) | Chemokine Receptor Type 2b (CCR2b) | Monocyte chemotactic protein-1 (MCP-1)
Type:
Enzyme
Mol. Mass.:
41932.32
Organism:
Homo sapiens (Human)
Description:
P41597
Residue:
374
Sequence:
MLSTSRSRFIRNTNESGEEVTTFFDYDYGAPCHKFDVKQIGAQLLPPLYSLVFIFGFVGNMLVVLILINCKKLKCLTDIYLLNLAISDLLFLITLPLWAHSAANEWVFGNAMCKLFTGLYHIGYFGGIFFIILLTIDRYLAIVHAVFALKARTVTFGVVTSVITWLVAVFASVPGIIFTKCQKEDSVYVCGPYFPRGWNNFHTIMRNILGLVLPLLIMVICYSGILKTLLRCRNEKKRHRAVRVIFTIMIVYFLFWTPYNIVILLNTFQEFFGLSNCESTSQLDQATQVTETLGMTHCCINPIIYAFVGEKFRSLFHIALGCRIAPLQKPVCGGPGVRPGKNVKVTTQGLLDGRGKGKSIGRAPEASLQDKEGA
  
Inhibitor
Name:
BDBM50274434
Synonyms:
CHEMBL4128658
Type:
Small organic molecule
Emp. Form.:
C27H37Cl2N5O3S
Mol. Mass.:
582.585
SMILES:
CN(C1CCN(CCCN2CCCc3c(NCCc4ccc(Cl)c(Cl)c4)nccc3C2=O)CC1)S(C)(=O)=O
Structure:
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