Reaction Details Report a problem with these data
Target
Solute carrier family 2, facilitated glucose transporter member 14
Ligand
BDBM50277373
Substrate
n/a
Meas. Tech.
ChEMBL_1717902 (CHEMBL4132902)
IC50
>100000±n/a nM
Citation
 Wei, C; Bajpai, R; Sharma, H; Heitmeier, M; Jain, AD; Matulis, SM; Nooka, AK; Mishra, RK; Hruz, PW; Schiltz, GE; Shanmugam, M Development of GLUT4-selective antagonists for multiple myeloma therapy. Eur J Med Chem 139:573-586 (2017) [PubMed]  Article 
Target
Name:
Solute carrier family 2, facilitated glucose transporter member 14
Synonyms:
GLUT-14 | GLUT14 | GTR14_HUMAN | Glucose transporter type 14 | SLC2A14 | Solute carrier family 2, facilitated glucose transporter member 14
Type:
PROTEIN
Mol. Mass.:
56324.51
Organism:
Homo sapiens
Description:
ChEMBL_118151
Residue:
520
Sequence:
MEFHNGGHVSGIGGFLVSLTSRMKPHTLAVTPALIFAITVATIGSFQFGYNTGVINAPETIIKEFINKTLTDKANAPPSEVLLTNLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLLAATGGCLMGLCKIAESVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVIGILVAQIFGLELILGSEELWPVLLGFTILPAILQSAALPCCPESPRFLLINRKKEENATRILQRLWGTQDVSQDIQEMKDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQQPIYATISAGVVNTIFTLLSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKNHYNGMSFVCIGAILVFVACFEIGPGPIPWFIVAELFSQGPRPAAMAVAGCSNWTSNFLVGLLFPSAAYYLGAYVFIIFTGFLITFLAFTFFKVPETRGRTFEDITRAFEGQAHGADRSGKDGVMGMNSIEPAKETTTNV
  
Inhibitor
Name:
BDBM50277373
Synonyms:
CHEMBL4165190
Type:
Small organic molecule
Emp. Form.:
C30H29FN2O3
Mol. Mass.:
484.5613
SMILES:
COc1ccc(CC(=O)N(Cc2ccncc2)Cc2cccc(OCCc3ccc(F)cc3)c2)cc1
Structure:
Search PDB for entries with ligand similarity: