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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50282652
Substrate
n/a
Meas. Tech.
ChEMBL_1724479 (CHEMBL4139757)
IC50
650±n/a nM
Citation
 Deplano, A; Morgillo, CM; Demurtas, M; Björklund, E; Cipriano, M; Svensson, M; Hashemian, S; Smaldone, G; Pedone, E; Luque, FJ; Cabiddu, MG; Novellino, E; Fowler, CJ; Catalanotti, B; Onnis, V Novel propanamides as fatty acid amide hydrolase inhibitors. Eur J Med Chem 136:523-542 (2017) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH | FAAH1 | FAAH1_HUMAN | Fatty Acid Amide Hydrolase (FAAH) | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Protein
Mol. Mass.:
63071.19
Organism:
Homo sapiens (Human)
Description:
O00519
Residue:
579
Sequence:
MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS
  
Inhibitor
Name:
BDBM50282652
Synonyms:
CHEMBL4159451
Type:
Small organic molecule
Emp. Form.:
C21H19FN2O
Mol. Mass.:
334.3868
SMILES:
C[C@@H](C(=O)Nc1ncccc1C)c1ccc(c(F)c1)-c1ccccc1 |r|
Structure:
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