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Target
Fatty-acid amide hydrolase 1
Ligand
BDBM50282653
Substrate
n/a
Meas. Tech.
ChEMBL_1724469 (CHEMBL4139747)
Ki
3000±n/a nM
Citation
 Deplano, A; Morgillo, CM; Demurtas, M; Björklund, E; Cipriano, M; Svensson, M; Hashemian, S; Smaldone, G; Pedone, E; Luque, FJ; Cabiddu, MG; Novellino, E; Fowler, CJ; Catalanotti, B; Onnis, V Novel propanamides as fatty acid amide hydrolase inhibitors. Eur J Med Chem 136:523-542 (2017) [PubMed]  Article 
Target
Name:
Fatty-acid amide hydrolase 1
Synonyms:
Anandamide amidohydrolase | Anandamide amidohydrolase 1 | FAAH1_MOUSE | Faah | Faah1 | Fatty Acid Amide Hydrolase | Fatty-acid amide hydrolase (FAAH) | Fatty-acid amide hydrolase 1 | Oleamide hydrolase 1
Type:
Hydrolase; single-pass membrane protein; homodimer
Mol. Mass.:
63227.28
Organism:
Mus musculus (mouse)
Description:
Mouse brain membranes were used in the assay.
Residue:
579
Sequence:
MVLSEVWTALSGLSGVCLACSLLSAAVVLRWTRSQTARGAVTRARQKQRAGLETMDKAVQRFRLQNPDLDSEALLALPLLQLVQKLQSGELSPEAVLFTYLGKAWEVNKGTNCVTSYLTDCETQLSQAPRQGLLYGVPVSLKECFSYKGHASTLGLSLNEGVTSESDCVVVQVLKLQGAVPFVHTNVPQSMLSYDCSNPLFGQTMNPWKPSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSAFCGICGLKPTGNRLSKSGLKSCVYGQTAVQLSVGPMARDVDSLALCMKALLCEDLFRLDSTIPPLPFREEIYRSSRPLRVGYYETDNYTMPTPAMRRAVMETKQSLEAAGHTLVPFLPNNIPYALEVLSAGGLFSDGGCSFLQNFKGDFVDPCLGDLVLVLKLPRWFKKLLSFLLKPLFPRLAAFLNSMCPRSAEKLWELQHEIEMYRQSVIAQWKAMNLDVVLTPMLGPALDLNTPGRATGAISYTVLYNCLDFPAGVVPVTTVTAEDDAQMEHYKGYFGDMWDNILKKGMKKGIGLPVAVQCVALPWQEELCLRFMREVERLMTPEKRPS
  
Inhibitor
Name:
BDBM50282653
Synonyms:
CHEMBL4163689
Type:
Small organic molecule
Emp. Form.:
C20H16ClF3N4O
Mol. Mass.:
420.815
SMILES:
CC(C(=O)Nc1ncccc1Cl)c1ccc(Nc2ccnc(c2)C(F)(F)F)cc1
Structure:
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