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Target
Sodium-dependent phosphate transport protein 2C
Ligand
BDBM50327362
Substrate
n/a
Meas. Tech.
ChEMBL_1734217 (CHEMBL4149753)
IC50
1900±n/a nM
Citation
 Filipski, KJ; Sammons, MF; Bhattacharya, SK; Panteleev, J; Brown, JA; Loria, PM; Boehm, M; Smith, AC; Shavnya, A; Conn, EL; Song, K; Weng, Y; Facemire, C; Jüppner, H; Clerin, V Discovery of Orally Bioavailable Selective Inhibitors of the Sodium-Phosphate Cotransporter NaPi2a (SLC34A1). ACS Med Chem Lett 9:440-445 (2018) [PubMed]  Article 
Target
Name:
Sodium-dependent phosphate transport protein 2C
Synonyms:
NPT2C | NPT2C_HUMAN | NPTIIC | Na(+)-dependent phosphate cotransporter 2C | Na(+)/Pi cotransporter 2C | NaPi-2c | SLC34A3 | Sodium-dependent phosphate transport protein 2C | Sodium-phosphate transport protein 2C | Sodium/inorganic phosphate cotransporter IIC | Sodium/phosphate cotransporter 2C | Solute carrier family 34 member 3
Type:
PROTEIN
Mol. Mass.:
63559.05
Organism:
Homo sapiens
Description:
ChEMBL_118145
Residue:
599
Sequence:
MPSSLPGSQVPHPTLDAVDLVEKTLRNEGTSSSAPVLEEGDTDPWTLPQLKDTSQPWKELRVAGRLRRVAGSVLKACGLLGSLYFFICSLDVLSSAFQLLGSKVAGDIFKDNVVLSNPVAGLVIGVLVTALVQSSSTSSSIVVSMVAAKLLTVRVSVPIIMGVNVGTSITSTLVSMAQSGDRDEFQRAFSGSAVHGIFNWLTVLVLLPLESATALLERLSELALGAASLTPRAQAPDILKVLTKPLTHLIVQLDSDMIMSSATGNATNSSLIKHWCGTTGQPTQENSSCGAFGPCTEKNSTAPADRLPCRHLFAGTELTDLAVGCILLAGSLLVLCGCLVLIVKLLNSVLRGRVAQVVRTVINADFPFPLGWLGGYLAVLAGAGLTFALQSSSVFTAAVVPLMGVGVISLDRAYPLLLGSNIGTTTTALLAALASPADRMLSALQVALIHFFFNLAGILLWYLVPALRLPIPLARHFGVVTARYRWVAGVYLLLGFLLLPLAAFGLSLAGGMELAAVGGPLVGLVLLVILVTVLQRRRPAWLPVRLRSWAWLPVWLHSLEPWDRLVTRCCPCNVCSPPKATTKEAYCYENPEILASQQL
  
Inhibitor
Name:
BDBM50327362
Synonyms:
CHEMBL4159390
Type:
Small organic molecule
Emp. Form.:
C25H23ClFN3O4S
Mol. Mass.:
515.984
SMILES:
OCC(O)CSCc1cccc(c1)C(=O)Nc1ccc(Cl)cc1C(=O)N\N=C\c1cccc(F)c1
Structure:
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