Reaction Details Report a problem with these data
Target
Discoidin domain-containing receptor 2
Ligand
BDBM50368549
Substrate
n/a
Meas. Tech.
ChEMBL_1736073 (CHEMBL4151609)
IC50
1540±n/a nM
Citation
 Wang, Z; Zhang, Y; Pinkas, DM; Fox, AE; Luo, J; Huang, H; Cui, S; Xiang, Q; Xu, T; Xun, Q; Zhu, D; Tu, Z; Ren, X; Brekken, RA; Bullock, AN; Liang, G; Ding, K; Lu, X Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem 61:7977-7990 (2018) [PubMed]  Article 
Target
Name:
Discoidin domain-containing receptor 2
Synonyms:
DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10
Type:
Protein
Mol. Mass.:
96717.07
Organism:
Homo sapiens (Human)
Description:
Q16832
Residue:
855
Sequence:
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
  
Inhibitor
Name:
BDBM50368549
Synonyms:
CHEMBL4171235
Type:
Small organic molecule
Emp. Form.:
C28H28F3N3O2
Mol. Mass.:
495.536
SMILES:
CCc1ccc(cc1C#Cc1ccoc1)C(=O)Nc1cc(CN2CCN(C)CC2)cc(c1)C(F)(F)F
Structure:
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