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Target
Delta-type opioid receptor
Ligand
BDBM50370393
Substrate
n/a
Meas. Tech.
ChEMBL_1737505 (CHEMBL4153255)
Ki
1130±n/a nM
Citation
 Ahonen, TJ; Rinne, M; Grutschreiber, P; Mätlik, K; Airavaara, M; Schaarschmidt, D; Lang, H; Reiss, D; Xhaard, H; Gaveriaux-Ruff, C; Yli-Kauhaluoma, J; Moreira, VM Synthesis of 7?-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors. Eur J Med Chem 151:495-507 (2018) [PubMed]  Article 
Target
Name:
Delta-type opioid receptor
Synonyms:
D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40382.98
Organism:
Homo sapiens (Human)
Description:
Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor.
Residue:
372
Sequence:
MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVCAVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELLCKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVGVPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRLRSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAALHLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTACTPSDGPGGGAAA
  
Inhibitor
Name:
BDBM50370393
Synonyms:
CHEMBL4168247
Type:
Small organic molecule
Emp. Form.:
C18H19NO7
Mol. Mass.:
361.346
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC[C@@]14[C@@]5([H])C(=O)[C@@H](O)[C@@H]2O)C(=O)OC)ccc3O |r,THB:21:9:13:4.5.6|
Structure:
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