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Target
Mu-type opioid receptor
Ligand
BDBM50370393
Substrate
n/a
Meas. Tech.
ChEMBL_1737504 (CHEMBL4153254)
Ki
1080±n/a nM
Citation
 Ahonen, TJ; Rinne, M; Grutschreiber, P; Mätlik, K; Airavaara, M; Schaarschmidt, D; Lang, H; Reiss, D; Xhaard, H; Gaveriaux-Ruff, C; Yli-Kauhaluoma, J; Moreira, VM Synthesis of 7?-hydroxy-8-ketone opioid derivatives with antagonist activity at mu- and delta-opioid receptors. Eur J Med Chem 151:495-507 (2018) [PubMed]  Article 
Target
Name:
Mu-type opioid receptor
Synonyms:
M-OR-1 | MOP | MOR-1 | MOR1 | MUOR1 | Mu Opioid Receptor | Mu opiate receptor | OPIATE Mu | OPRM1 | OPRM_HUMAN | hMOP | mu-type opioid receptor isoform MOR-1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44789.51
Organism:
Homo sapiens (Human)
Description:
P35372
Residue:
400
Sequence:
MDSSAAPTNASNCTDALAYSSCSPAPSPGSWVNLSHLDGNLSDPCGPNRTDLGGRDSLCPPTGSPSMITAITIMALYSIVCVVGLFGNFLVMYVIVRYTKMKTATNIYIFNLALADALATSTLPFQSVNYLMGTWPFGTILCKIVISIDYYNMFTSIFTLCTMSVDRYIAVCHPVKALDFRTPRNAKIINVCNWILSSAIGLPVMFMATTKYRQGSIDCTLTFSHPTWYWENLLKICVFIFAFIMPVLIITVCYGLMILRLKSVRMLSGSKEKDRNLRRITRMVLVVVAVFIVCWTPIHIYVIIKALVTIPETTFQTVSWHFCIALGYTNSCLNPVLYAFLDENFKRCFREFCIPTSSNIEQQNSTRIRQNTRDHPSTANTVDRTNHQLENLEAETAPLP
  
Inhibitor
Name:
BDBM50370393
Synonyms:
CHEMBL4168247
Type:
Small organic molecule
Emp. Form.:
C18H19NO7
Mol. Mass.:
361.346
SMILES:
[H][C@@]12Oc3c4c(C[C@@]5([H])N(CC[C@@]14[C@@]5([H])C(=O)[C@@H](O)[C@@H]2O)C(=O)OC)ccc3O |r,THB:21:9:13:4.5.6|
Structure:
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