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Target
Carbonic anhydrase 2
Ligand
BDBM50378416
Substrate
n/a
Meas. Tech.
ChEMBL_1738087 (CHEMBL4153837)
Ki
172±n/a nM
Citation
 Ibrahim, HS; Allam, HA; Mahmoud, WR; Bonardi, A; Nocentini, A; Gratteri, P; Ibrahim, ES; Abdel-Aziz, HA; Supuran, CT Dual-tail arylsulfone-based benzenesulfonamides differently match the hydrophobic and hydrophilic halves of human carbonic anhydrases active sites: Selective inhibitors for the tumor-associated hCA IX isoform. Eur J Med Chem 152:1-9 (2018) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Human
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50378416
Synonyms:
CHEMBL4170925
Type:
Small organic molecule
Emp. Form.:
C26H23N3O4S2
Mol. Mass.:
505.609
SMILES:
NS(=O)(=O)c1ccc(N\N=C(/CS(=O)(=O)c2ccccc2)c2ccc(cc2)-c2ccccc2)cc1
Structure:
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