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Target
NAD-dependent protein deacetylase
Ligand
BDBM50453759
Substrate
n/a
Meas. Tech.
ChEMBL_1750469 (CHEMBL4185229)
IC50
5700±n/a nM
Citation
 Hailu, GS; Robaa, D; Forgione, M; Sippl, W; Rotili, D; Mai, A Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. J Med Chem 60:4780-4804 (2017) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase
Synonyms:
Putative silent information regulator 2 | SIR2-like protein | SIR2RP1
Type:
PROTEIN
Mol. Mass.:
40532.98
Organism:
Leishmania infantum
Description:
ChEMBL_936768
Residue:
373
Sequence:
MTASPRAPHQEHVLGEPTLEGLAHYIREKNVRRILVLVGAGASVAAGIPDFRSPDTGIYANLGKYNLEDPTDAFSLTLLREKPEIFYSIARELNLWPGHFQPTAVHHFIRLLQDEGRLLRCCTQNIDGLEKAAGVSPELLVEAHGSFAAAACIECHTPFSIEQNYLEAMSGTVSRCSTCGGIVKPNVVFFGENLPDAFFDALHHDAPIAELVIIIGTSMQVHPFALLPCVVPKSVPRVVMNRERVGGLLFRFPDDPLNTVHEDAVAKEGRSSSSQSRSPSASPRREEGGTEDSPSSPNEEVEEASTSSSSDGYGQYGDYHAHPDVCRDVLFRGDCQENVVTLAEYLGLSEALAKRMRLSDAAPATAQRAPNET
  
Inhibitor
Name:
BDBM50453759
Synonyms:
CHEMBL4205986
Type:
Small organic molecule
Emp. Form.:
C38H48Br4N6O4
Mol. Mass.:
972.442
SMILES:
Br.Br.Br.Br.O=C1N(CCNCCCNCCCCNCCCNCCN2C(=O)c3cccc4cccc(C2=O)c34)C(=O)c2cccc3cccc1c23
Structure:
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