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Target
Histone deacetylase 1
Ligand
BDBM50239016
Substrate
n/a
Meas. Tech.
ChEMBL_1750452 (CHEMBL4185212)
IC50
19400±n/a nM
Citation
 Hailu, GS; Robaa, D; Forgione, M; Sippl, W; Rotili, D; Mai, A Lysine Deacetylase Inhibitors in Parasites: Past, Present, and Future Perspectives. J Med Chem 60:4780-4804 (2017) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50239016
Synonyms:
CHEMBL2094337 | DNDI1416947
Type:
Small organic molecule
Emp. Form.:
C9H6ClNO2S
Mol. Mass.:
227.667
SMILES:
ONC(=O)c1sc2ccccc2c1Cl
Structure:
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