Reaction Details Report a problem with these data
Target
Lipopolysaccharide heptosyltransferase 1
Ligand
BDBM50454779
Substrate
n/a
Meas. Tech.
ChEMBL_1753351 (CHEMBL4188111)
Ki
650000±n/a nM
Citation
 Nkosana, NK; Czyzyk, DJ; Siegel, ZS; Cote, JM; Taylor, EA Synthesis, kinetics and inhibition of Escherichia coli Heptosyltransferase I by monosaccharide analogues of Lipid A. Bioorg Med Chem Lett 28:594-600 (2018) [PubMed]  Article 
Target
Name:
Lipopolysaccharide heptosyltransferase 1
Synonyms:
2.-.-.- | Lipopolysaccharide heptosyltransferase 1 | RFAC_ECOLI | rfa-2 | rfaC | waaC | yibC
Type:
PROTEIN
Mol. Mass.:
35553.92
Organism:
Escherichia coli (strain K12)
Description:
ChEMBL_117821
Residue:
319
Sequence:
MRVLIVKTSSMGDVLHTLPALTDAQQAIPGIKFDWVVEEGFAQIPSWHAAVERVIPVAIRRWRKAWFSAPIKAERKAFREALQAENYDAVIDAQGLVKSAALVTRLAHGVKHGMDWQTAREPLASLFYNRKHHIAKQQHAVERTRELFAKSLGYSKPQTQGDYAIAQHFLTNLPTDAGEYAVFLHATTRDDKHWPEEHWRELIGLLADSGIRIKLPWGAPHEEERAKRLAEGFAYVEVLPKMSLEGVARVLAGAKFVVSVDTGLSHLTAALDRPNITVYGPTDPGLIGGYGKNQMVCRAPRENLINLNSQAVLEKLSSL
  
Inhibitor
Name:
BDBM50454779
Synonyms:
CHEMBL4213641
Type:
Small organic molecule
Emp. Form.:
C9H16O6
Mol. Mass.:
220.2197
SMILES:
OC[C@H]1O[C@@H](OCC=C)[C@H](O)[C@@H](O)[C@@H]1O |r|
Structure:
Search PDB for entries with ligand similarity: