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Target
Nuclear receptor ROR-gamma
Ligand
BDBM50461075
Substrate
n/a
Meas. Tech.
ChEMBL_1770666 (CHEMBL4222778)
IC50
34±n/a nM
Citation
Ouvry, G; Bihl, F; Bouix-Peter, C; Christin, O; Defoin-Platel, C; Deret, S; Feret, C; Froude, D; Hacini-Rachinel, F; Harris, CS; Hervouet, C; Lafitte, G; Luzy, AP; Musicki, B; Orfila, D; Parnet, V; Pascau, C; Pascau, J; Pierre, R; Raffin, C; Rossio, P; Spiesse, D; Taquet, N; Thoreau, E; Vatinel, R; Vial, E; Hennequin, LF Sulfoximines as potent ROR? inverse agonists. Bioorg Med Chem Lett 28:1269-1273 (2018) [PubMed] Article
More Info.:
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Human
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK