Reaction Details Report a problem with these data
Target
Glycogen synthase kinase-3 beta/[Tau protein] kinase
Ligand
BDBM50463024
Substrate
n/a
Meas. Tech.
ChEMBL_1777052 (CHEMBL4234044)
IC50
750±n/a nM
Citation
Winfield, HJ; Cahill, MM; O'Shea, KD; Pierce, LT; Robert, T; Ruchaud, S; Bach, S; Marchand, P; McCarthy, FO Synthesis and anticancer activity of novel bisindolylhydroxymaleimide derivatives with potent GSK-3 kinase inhibition. Bioorg Med Chem 26:4209-4224 (2018) [PubMed] Article
More Info.:
Target
Name:
Glycogen synthase kinase-3 beta/[Tau protein] kinase
Synonyms:
Glycogen synthase kinase-3
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 2105817
Components:
This complex has 2 components.
Component 1
Name:
Glycogen synthase kinase-3 beta
Synonyms:
Glycogen synthase kinase 3 beta | Glycogen synthase kinase-3
Type:
PROTEIN
Mol. Mass.:
46774.42
Organism:
Pig
Description:
ChEMBL_939732
Residue:
420
Sequence:
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTMVATPGQGPDRPQEVSYTDAKVIGNGSFGVVYQAKLCDSGELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDEVYLNLVLDYVPETVYRVARHYSRAKQTLPVIYVKLYMYQLFRSLAYIHSFGICHRDIKPQNLLLDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATDYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFRPRTPPEAIALCSRLLEYTPTARLTPLEACAHSFFDELRDPNVKLPNGRDTPALFNFTTQELSSNPPLATILIPPHARIQAAASTPSNATAASDTNAGDRGQTNNTASASASNST
Component 2
Name:
[Tau protein] kinase
Synonyms:
GSK3A | Glycogen synthase kinase 3 alpha
Type:
PROTEIN
Mol. Mass.:
51010.29
Organism:
Pig
Description:
ChEMBL_117799
Residue:
483
Sequence:
MSGGAPSGGGPGGSGRARTSSFAEHGGGGGGSGGGPGGSASGPGGGGGGKPSVGAMGGGVGASSSGGGPSGSGGGGSGGPGAGTSFPPPGVKLGRDSGKVTTVVATLGQGPERSQEVAYTDIKVIGNGSFGVVYQARLADTRELVAIKKVLQDKRFKNRELQIMRKLDHCNIVRLRYFFYSSGEKKDELYLNLVLEYVPETVYRVARHFTKAKLTIPIIYVKVYMYQLFRSLAYIHSQGVCHRDIKPQNLLVDPDTAVLKLCDFGSAKQLVRGEPNVSYICSRYYRAPELIFGATGYTSSIDVWSAGCVLAELLLGQPIFPGDSGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKAHPWTKVFKSRTPPEAITLCSSLLEYTPSSRLSPLEACAHNFFDELRCPGTQLPNNRPLPPLFNFSPGELTIQPSLNAILIPPHLRSPAGTASLTSSSQALSETPTGPDWQSTDATTPLTNSS