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Target
Dihydrofolate reductase
Ligand
BDBM50024470
Substrate
n/a
Meas. Tech.
ChEBML_54896
IC50
>200000±n/a nM
Citation
 Nair, MG; Dhawan, R; Ghazala, M; Kalman, TI; Ferone, R; Gaumont, Y; Kisliuk, RL Folate analogues. 30. Synthesis and biological evaluation of N10-propargyl-5,8-dideaza-5,6,7,8-tetrahydrofolic acid and related compounds. J Med Chem 30:1256-61 (1987) [PubMed]  Article 
Target
Name:
Dihydrofolate reductase
Synonyms:
DYR_LACCA | dhfR | folA
Type:
PROTEIN
Mol. Mass.:
18437.08
Organism:
Lactobacillus casei
Description:
ChEMBL_1357878
Residue:
163
Sequence:
MTAFLWAQDRDGLIGKDGHLPWHLPDDLHYFRAQTVGKIMVVGRRTYESFPKRPLPERTNVVLTHQEDYQAQGAVVVHDVAAVFAYAKQHPDQELVIAGGAQIFTAFKDDVDTLLVTRLAGSFEGDTKMIPLNWDDFTKVSSRTVEDTNPALTHTYEVWQKKA
  
Inhibitor
Name:
BDBM50024470
Synonyms:
4-[(2-Amino-4-oxo-3,4,5,6,7,8-hexahydro-quinazolin-6-ylmethyl)-methyl-amino]-benzoic acid | CHEMBL22449
Type:
Small organic molecule
Emp. Form.:
C17H20N4O3
Mol. Mass.:
328.3657
SMILES:
CN(CC1CCc2nc(N)[nH]c(=O)c2C1)c1ccc(cc1)C(O)=O
Structure:
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