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Target
Adenosylhomocysteinase
Ligand
BDBM50465905
Substrate
n/a
Meas. Tech.
ChEMBL_1789036 (CHEMBL4260770)
IC50
8.7±n/a nM
Citation
 Liu, C; Chen, Q; Cardinale, S; Bowlin, TL; Schneller, SW 6'-Fluoro-3-deazaneplanocin: Synthesis and antiviral properties, including Ebola. Bioorg Med Chem Lett 28:3674-3675 (2018) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | S-Adenosylhomocysteine Hydrolase | SAHase
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58521.01
Organism:
Oryctolagus cuniculus (Rabbit)
Description:
n/a
Residue:
536
Sequence:
MKGTIMARCPLGKPSRRSIDSTGQNSESGAGIEVHSGHAPVRGPRPCRLSLSGTHEYAKRGRYLKAPAPRADSCPAPPAQCLISALGLIPFSPVCITACSNAARMSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMREMYSASKPLKGARIAGCLHMTVETAVLIETLVALGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLSGIRGISEETTTGVHNLYKMMANGVLKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACKEGNIFVTTTGCVDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYWLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVLAQIELWTHPDKYAVGVHFLPKKLDEAVAEAHLSKLNVKLTKLTEKQAQYLGMSRDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50465905
Synonyms:
CHEMBL4285617
Type:
Small organic molecule
Emp. Form.:
C13H14FN3O3
Mol. Mass.:
279.267
SMILES:
Nc1cccc2n(cnc12)[C@H]1[C@H](O)[C@H](O)C(CO)=C1F |r,c:19|
Structure:
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