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Target
Glucagon receptor
Ligand
BDBM50466420
Substrate
n/a
Meas. Tech.
ChEMBL_1793149 (CHEMBL4265068)
IC50
6000±n/a nM
Citation
 Choi, H; Lee, CY; Park, EY; Lee, KM; Shin, D; Jun, HS Design, synthesis, and effects of novel phenylpyrimidines as glucagon receptor antagonists. Bioorg Med Chem 26:5701-5710 (2018) [PubMed]  Article 
Target
Name:
Glucagon receptor
Synonyms:
GCGR | GL-R | GLR_HUMAN | Glucagon Receptor (GCGR) | Glucagon receptor (GlucR)
Type:
Enzyme
Mol. Mass.:
54026.92
Organism:
Homo sapiens (Human)
Description:
P47871
Residue:
477
Sequence:
MPPCQPQRPLLLLLLLLACQPQVPSAQVMDFLFEKWKLYGDQCHHNLSLLPPPTELVCNRTFDKYSCWPDTPANTTANISCPWYLPWHHKVQHRFVFKRCGPDGQWVRGPRGQPWRDASQCQMDGEEIEVQKEVAKMYSSFQVMYTVGYSLSLGALLLALAILGGLSKLHCTRNAIHANLFASFVLKASSVLVIDGLLRTRYSQKIGDDLSVSTWLSDGAVAGCRVAAVFMQYGIVANYCWLLVEGLYLHNLLGLATLPERSFFSLYLGIGWGAPMLFVVPWAVVKCLFENVQCWTSNDNMGFWWILRFPVFLAILINFFIFVRIVQLLVAKLRARQMHHTDYKFRLAKSTLTLIPLLGVHEVVFAFVTDEHAQGTLRSAKLFFDLFLSSFQGLLVAVLYCFLNKEVQSELRRRWHRWRLGKVLWEERNTSNHRASSSPGHGPPSKELQFGRGGGSQDSSAETPLAGGLPRLAESPF
  
Inhibitor
Name:
BDBM50466420
Synonyms:
CHEMBL4284236
Type:
Small organic molecule
Emp. Form.:
C29H35N3O4
Mol. Mass.:
489.6059
SMILES:
CCCCC(Oc1ncc(cn1)-c1ccc(cc1)C(C)(C)C)c1ccc(cc1)C(=O)NCCC(O)=O
Structure:
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