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Target
Sodium- and chloride-dependent GABA transporter 2
Ligand
BDBM50466786
Substrate
n/a
Meas. Tech.
ChEMBL_1793938 (CHEMBL4265857)
IC50
9550±n/a nM
Citation
 Tóth, K; Höfner, G; Wanner, KT Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with a trans-alkene spacer as potent GABA uptake inhibitors. Bioorg Med Chem 26:5944-5961 (2018) [PubMed]  Article 
Target
Name:
Sodium- and chloride-dependent GABA transporter 2
Synonyms:
GABA transporter | GABA transporter 3 | Gabt2 | Gabt3 | Gat-3 | Gat2 | Gat3 | S6A13_MOUSE | Slc6a13
Type:
PROTEIN
Mol. Mass.:
68283.40
Organism:
Mus musculus
Description:
ChEMBL_1460089
Residue:
602
Sequence:
MENRASGTTSNGETKPVCPAMEKVEEDGTLEREHWNNKMEFVLSVAGEIIGLGNVWRFPYLCYKNGGGAFFIPYLIFLFTCGIPVFFLETALGQYTNQGGITAWRRICPIFEGIGYASQMIVSLLNVYYIVVLAWALFYLFSSFTTDLPWGSCSHEWNTENCVEFQKANDSMNVTSENATSPVIEFWERRVLKLSDGIQHLGSLRWELVLCLLLAWIICYFCIWKGVKSTGKVVYFTATFPYLMLVVLLIRGVTLPGAAQGIQFYLYPNITRLWDPQVWMDAGTQIFFSFAICLGCLTALGSYNKYHNNCYRDCIALCILNSSTSFMAGFAIFSILGFMSQEQGVPISEVAESGPGLAFIAYPRAVVMLPFSPLWACCFFFMVVLLGLDSQFVCVESLVTALVDMYPRVFRKKNRREVLILIVSVISFFIGLIMLTEGGMYVFQLFDYYAASGMCLLFVAIFESLCVAWVYGAGRFYDNIEDMIGYKPWPLIKYCWLFFTPAVCLATFLFSLIKYTPLTYNKKYTYPWWGDALGWLLALSSMICIPAWSIYKLRTLKGPLRERLRQLVCPAEDLPQKNQPEPTAPATPMTSLLRLTELESNC
  
Inhibitor
Name:
BDBM50466786
Synonyms:
CHEMBL4284560
Type:
Small organic molecule
Emp. Form.:
C34H29NO5
Mol. Mass.:
531.5978
SMILES:
OC(=O)C1CCCN(C\C=C\C(c2ccc3occc3c2)(c2ccc3occc3c2)c2ccc3occc3c2)C1
Structure:
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