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Target
Monoglyceride lipase
Ligand
BDBM50414921
Substrate
n/a
Meas. Tech.
ChEMBL_1802954 (CHEMBL4275246)
IC50
140±n/a nM
Citation
 Bononi, G; Granchi, C; Lapillo, M; Giannotti, M; Nieri, D; Fortunato, S; Boustani, ME; Caligiuri, I; Poli, G; Carlson, KE; Kim, SH; Macchia, M; Martinelli, A; Rizzolio, F; Chicca, A; Katzenellenbogen, JA; Minutolo, F; Tuccinardi, T Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors. Eur J Med Chem 157:817-836 (2018) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Human
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50414921
Synonyms:
CHEMBL570812
Type:
Small organic molecule
Emp. Form.:
C18H17N3O5
Mol. Mass.:
355.3447
SMILES:
COc1nn(-c2ccc(NC(=O)OCc3ccccc3)c(C)c2)c(=O)o1
Structure:
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