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Target
Histone acetyltransferase KAT8
Ligand
BDBM50470500
Substrate
n/a
Meas. Tech.
ChEMBL_1802988 (CHEMBL4275280)
IC50
40000±n/a nM
Citation
 Zhang, R; Wang, J; Zhao, L; Liu, S; Du, D; Ding, H; Chen, S; Yue, L; Liu, YC; Zhang, C; Liu, H; Luo, C Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening. Eur J Med Chem 157:867-876 (2018) [PubMed]  Article 
Target
Name:
Histone acetyltransferase KAT8
Synonyms:
KAT8 | KAT8_HUMAN | Lysine acetyltransferase 8 | MOF | MOZ, YBF2/SAS3, SAS2 and TIP60 protein 1 | MYST-1 | MYST1 | hMOF
Type:
PROTEIN
Mol. Mass.:
52413.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_796800
Residue:
458
Sequence:
MAAQGAAAAVAAGTSGVAGEGEPGPGENAAAEGTAPSPGRVSPPTPARGEPEVTVEIGETYLCRRPDSTWHSAEVIQSRVNDQEGREEFYVHYVGFNRRLDEWVDKNRLALTKTVKDAVQKNSEKYLSELAEQPERKITRNQKRKHDEINHVQKTYAEMDPTTAALEKEHEAITKVKYVDKIHIGNYEIDAWYFSPFPEDYGKQPKLWLCEYCLKYMKYEKSYRFHLGQCQWRQPPGKEIYRKSNISVYEVDGKDHKIYCQNLCLLAKLFLDHKTLYFDVEPFVFYILTEVDRQGAHIVGYFSKEKESPDGNNVACILTLPPYQRRGYGKFLIAFSYELSKLESTVGSPEKPLSDLGKLSYRSYWSWVLLEILRDFRGTLSIKDLSQMTSITQNDIISTLQSLNMVKYWKGQHVICVTPKLVEEHLKSAQYKKPPITVDSVCLKWAPPKHKQVKLSKK
  
Inhibitor
Name:
BDBM50470500
Synonyms:
CHEMBL4291334
Type:
Small organic molecule
Emp. Form.:
C19H19FN2O2S2
Mol. Mass.:
390.495
SMILES:
CCN(CC)S(=O)(=O)c1ccc(\C=C\c2nc3cc(F)ccc3s2)cc1
Structure:
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