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Target
Proteasome subunit beta type-2
Ligand
BDBM50470552
Substrate
n/a
Meas. Tech.
ChEMBL_1803098 (CHEMBL4275390)
IC50
3716±n/a nM
Citation
 Niroula, D; Hallada, LP; Le Chapelain, C; Ganegamage, SK; Dotson, D; Rogelj, S; Groll, M; Tello-Aburto, R Design, synthesis, and evaluation of cystargolide-based ?-lactones as potent proteasome inhibitors. Eur J Med Chem 157:962-977 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-2
Synonyms:
20S proteasome | PSB2_HUMAN | PSMB2 | Proteasome Macropain subunit
Type:
PROTEIN
Mol. Mass.:
22837.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1294233
Residue:
201
Sequence:
MEYLIGIQGPDYVLVASDRVAASNIVQMKDDHDKMFKMSEKILLLCVGEAGDTVQFAEYIQKNVQLYKMRNGYELSPTAAANFTRRNLADCLRSRTPYHVNLLLAGYDEHEGPALYYMDYLAALAKAPFAAHGYGAFLTLSILDRYYTPTISRERAVELLRKCLEELQKRFILNLPTFSVRIIDKNGIHDLDNISFPKQGS
  
Inhibitor
Name:
BDBM50470552
Synonyms:
CHEMBL4281941
Type:
Small organic molecule
Emp. Form.:
C29H36N2O6
Mol. Mass.:
508.6059
SMILES:
[H][C@]1([C@@H](C)CC)[C@@H](OC1=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)OCc1ccccc1 |r|
Structure:
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