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Target
Proteasome subunit beta type-8
Ligand
BDBM50470559
Substrate
n/a
Meas. Tech.
ChEMBL_1803099 (CHEMBL4275391)
IC50
41±n/a nM
Citation
 Niroula, D; Hallada, LP; Le Chapelain, C; Ganegamage, SK; Dotson, D; Rogelj, S; Groll, M; Tello-Aburto, R Design, synthesis, and evaluation of cystargolide-based ?-lactones as potent proteasome inhibitors. Eur J Med Chem 157:962-977 (2018) [PubMed]  Article 
Target
Name:
Proteasome subunit beta type-8
Synonyms:
26S proteosome | LMP7 | Low molecular mass protein 7 | Macropain subunit C13 | Multicatalytic endopeptidase complex subunit C13 | PSB8_HUMAN | PSMB5i | PSMB8 | Proteasome component C13 | Proteasome subunit beta type-8 | Proteasome subunit beta-5i | RING10 | Y2
Type:
PROTEIN
Mol. Mass.:
30357.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1446797
Residue:
276
Sequence:
MALLDVCGAPRGQRPESALPVAGSGRRSDPGHYSFSMRSPELALPRGMQPTEFFQSLGGDGERNVQIEMAHGTTTLAFKFQHGVIAAVDSRASAGSYISALRVNKVIEINPYLLGTMSGCAADCQYWERLLAKECRLYYLRNGERISVSAASKLLSNMMCQYRGMGLSMGSMICGWDKKGPGLYYVDEHGTRLSGNMFSTGSGNTYAYGVMDSGYRPNLSPEEAYDLGRRAIAYATHRDSYSGGVVNMYHMKEDGWVKVESTDVSDLLHQYREANQ
  
Inhibitor
Name:
BDBM50470559
Synonyms:
CHEMBL4285979
Type:
Small organic molecule
Emp. Form.:
C21H34N2O6
Mol. Mass.:
410.5045
SMILES:
[H][C@]1([C@@H](C)CC)[C@@H](OC1=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)OCC=C |r|
Structure:
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