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Target
Histamine H3 receptor
Ligand
BDBM50127607
Substrate
n/a
Meas. Tech.
ChEMBL_87060 (CHEMBL698090)
Ki
25±n/a nM
Citation
 De Esch, IJ; Vollinga, RC; Goubitz, K; Schenk, H; Appelberg, U; Hacksell, U; Lemstra, S; Zuiderveld, OP; Hoffmann, M; Leurs, R; Menge, WM; Timmerman, H Characterization of the binding site of the histamine H3 receptor. 1. Various approaches to the synthesis of 2-(1H-imidazol-4-yl)cyclopropylamine and histaminergic activity of (1R,2R)- and (1S,2S)-2-(1H-imidazol-4-yl)-cyclopropylamine. J Med Chem 42:1115-22 (1999) [PubMed]  Article 
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50127607
Synonyms:
(1R,2R)-2-(1H-Imidazol-4-yl)-cyclopropylamine | (1R,2R)-2-(3H-Imidazol-4-yl)-cyclopropylamine | 2-(1H-Imidazol-4-yl)-cyclopropylamine | CHEMBL13559 | VUF-5296
Type:
Small organic molecule
Emp. Form.:
C6H9N3
Mol. Mass.:
123.1558
SMILES:
N[C@@H]1C[C@H]1c1cnc[nH]1
Structure:
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