Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50475421
Substrate
n/a
Meas. Tech.
ChEMBL_321066 (CHEMBL872149)
Ki
2.0±n/a nM
Citation
 Wyman, PA; Marshall, HR; Flynn, ST; King, RJ; Thompson, M; Smith, PW; Hadley, MS; Price, GW; Scott, CM; Dawson, LA Identification of a potent and selective 5-HT1B receptor antagonist. Bioorg Med Chem Lett 15:4708-12 (2005) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Human
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50475421
Synonyms:
CHEMBL195114
Type:
Small organic molecule
Emp. Form.:
C31H32N4O2
Mol. Mass.:
492.6114
SMILES:
COc1cc2CCN(C(=O)c3ccc(-c4cccc(C)n4)c4ccccc34)c2cc1N1CCN(C)CC1
Structure:
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