Reaction Details Report a problem with these data
Target
Integrase
Ligand
BDBM50477983
Substrate
n/a
Meas. Tech.
ChEMBL_463503 (CHEMBL932798)
IC50
11±n/a nM
Citation
 Dayam, R; Al-Mawsawi, LQ; Zawahir, Z; Witvrouw, M; Debyser, Z; Neamati, N Quinolone 3-carboxylic acid pharmacophore: design of second generation HIV-1 integrase inhibitors. J Med Chem 51:1136-44 (2008) [PubMed]  Article 
Target
Name:
Integrase
Synonyms:
pol
Type:
PROTEIN
Mol. Mass.:
32203.43
Organism:
Human immunodeficiency virus 1
Description:
ChEMBL_106649
Residue:
288
Sequence:
FLDGIDKAQEEHEKYHSNWRAMASDFNLPPVVAKEIVASCDKCQLKGEAMHGQVDCSPGIWQLDCTHLEGKVILVAVHVASGYIEAEVIPAETGQETAYFLLKLAGRWPVKTVHTDNGSNFTSTTVKAACWWAGIKQEFGIPYNPQSQGVIESMNKELKKIIGQVRDQAEHLKTAVQMAVFIHNFKRKGGIGGYSAGERIVDIIATDIQTKELQKQITKIQNFRVYYRDSRDPVWKGPAKLLWKGEGAVVIQDNSDIKVVPRRKAKIIRDYGKQMAGDDCVASRQDED
  
Inhibitor
Name:
BDBM50477983
Synonyms:
CHEMBL272194
Type:
Small organic molecule
Emp. Form.:
C12H8Cl2N6O2
Mol. Mass.:
339.137
SMILES:
CC1=NN(C(=O)\C1=C/c1cc(Cl)c(O)c(Cl)c1)c1nnn[nH]1 |t:1|
Structure:
Search PDB for entries with ligand similarity: