Reaction Details Report a problem with these data
Target
5-hydroxytryptamine receptor 1B
Ligand
BDBM50478241
Substrate
n/a
Meas. Tech.
ChEMBL_474275 (CHEMBL934242)
Ki
<3162±n/a nM
Citation
 Witherington, J; Abberley, L; Briggs, MA; Collis, K; Dean, DK; Gaiba, A; King, NP; Kraus, H; Shuker, N; Steadman, JG; Takle, AK; Sanger, G; Wadsworth, G; Butler, S; McKay, F; Muir, A; Winborn, K; Heightman, TD Potent achiral agonists of the growth hormone secretagogue (ghrelin) receptor. Part 2: Lead optimisation. Bioorg Med Chem Lett 18:2203-5 (2008) [PubMed]  Article 
Target
Name:
5-hydroxytryptamine receptor 1B
Synonyms:
5-HT-1B | 5-HT-1D-beta | 5-HT1B | 5-hydroxytryptamine receptor 1B (5-HT1B) | 5HT1B_HUMAN | HTR1B | HTR1DB | S12 | Serotonin (5-HT) receptor | Serotonin 1D beta receptor | Serotonin Receptor 1B
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43579.17
Organism:
Homo sapiens (Human)
Description:
Receptor binding assays were performed using human clone stably expressed in CHO cells
Residue:
390
Sequence:
MEEPGAQCAPPPPAGSETWVPQANLSSAPSQNCSAKDYIYQDSISLPWKVLLVMLLALITLATTLSNAFVIATVYRTRKLHTPANYLIASLAVTDLLVSILVMPISTMYTVTGRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWAITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHILYTVYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDSPGSTSSVTSINSRVPDVPSESGSPVYVNQVKVRVSDALLEKKKLMAARERKATKTLGIILGAFIVCWLPFFIISLVMPICKDACWFHLAIFDFFTWLGYLNSLINPIIYTMSNEDFKQAFHKLIRFKCTS
  
Inhibitor
Name:
BDBM50478241
Synonyms:
CHEMBL256263
Type:
Small organic molecule
Emp. Form.:
C23H27N3O3S2
Mol. Mass.:
457.609
SMILES:
COc1ccc(cc1NS(=O)(=O)c1ccc(cc1)-c1cccs1)N1C[C@H](C)N[C@H](C)C1
Structure:
Search PDB for entries with ligand similarity: