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Target
72 kDa type IV collagenase
Ligand
BDBM50478728
Substrate
n/a
Meas. Tech.
ChEMBL_556818 (CHEMBL963904)
IC50
77000±n/a nM
Citation
 Uto, Y; Nagasawa, H; Jin, CZ; Nakayama, S; Tanaka, A; Kiyoi, S; Nakashima, H; Shimamura, M; Inayama, S; Fujiwara, T; Takeuchi, Y; Uehara, Y; Kirk, KL; Nakata, E; Hori, H Design of antiangiogenic hypoxic cell radiosensitizers: 2-nitroimidazoles containing a 2-aminomethylene-4-cyclopentene-1,3-dione moiety. Bioorg Med Chem 16:6042-53 (2008) [PubMed]  Article 
Target
Name:
72 kDa type IV collagenase
Synonyms:
72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1
Type:
Enzyme
Mol. Mass.:
73870.36
Organism:
Homo sapiens (Human)
Description:
P08253
Residue:
660
Sequence:
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGTSYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
  
Inhibitor
Name:
BDBM50478728
Synonyms:
CHEMBL490266 | TX-2036
Type:
Small organic molecule
Emp. Form.:
C29H28N4O7
Mol. Mass.:
544.5552
SMILES:
[#6]C([#6])([#6])c1ccc(-[#8]-[#6]-[#6@@H](-[#6]-n2ccnc2-[#7+](-[#8-])=O)-[#8]-[#6](=O)-c2ccc(-[#7]\[#6]=[#6]-3/[#6](=O)-[#6]=[#6]-[#6]-3=O)cc2)cc1 |r,c:33|
Structure:
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