Reaction Details Report a problem with these data
Target
Dihydrofolate reductase
Ligand
BDBM50026307
Substrate
n/a
Meas. Tech.
ChEBML_54543
Ki
0.370000±n/a nM
Citation
Kuyper, LF; Roth, B; Baccanari, DP; Ferone, R; Beddell, CR; Champness, JN; Stammers, DK; Dann, JG; Norrington, FE; Baker, DJ; Goodford, PJ Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues. J Med Chem 25:1120-2 (1983) [PubMed] Article
More Info.:
Target
Name:
Dihydrofolate reductase
Synonyms:
Dihydrofolate reductase (F31V) | dfrA17
Type:
n/a
Mol. Mass.:
17532.46
Organism:
Escherichia coli
Description:
n/a
Residue:
157
Sequence:
MKISLISAVSESGVIGSGPDIPWSVKGEQLLFKALTYNQWLLVGRKTFDSMGVLPNRKYAVVSKNGISSSNENVLVFPSIENALKELSKVTDHVYVSGGGQIYNSLIEKADIIHLSTVHVEVEGDIKFPIMPENFNLVFEQFFMSNINYTYQIWKKG