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Target
Thymidylate synthase
Ligand
BDBM50010239
Substrate
n/a
Meas. Tech.
ChEMBL_217700 (CHEMBL821239)
Ki
200±n/a nM
Citation
 Barr, PJ; Nolan, PA; Santi, DV; Robins, MJ Inhibition of thymidylate synthetase by 5-alkynyl-2'-deoxyuridylates. J Med Chem 24:1385-8 (1982) [PubMed]  Article 
Target
Name:
Thymidylate synthase
Synonyms:
TSase | TYSY_LACCA | Thymidylate Synthase (TS) | Thymidylate synthase | thyA
Type:
Enzyme
Mol. Mass.:
36576.54
Organism:
Lactobacillus casei
Description:
n/a
Residue:
316
Sequence:
MLEQPYLDLAKKVLDEGHFKPDRTHTGTYSIFGHQMRFDLSKGFPLLTTKKVPFGLIKSELLWFLHGDTNIRFLLQHRNHIWDEWAFEKWVKSDEYHGPDMTDFGHRSQKDPEFAAVYHEEMAKFDDRVLHDDAFAAKYGDLGLVYGSQWRAWHTSKGDTIDQLGDVIEQIKTHPYSRRLIVSAWNPEDVPTMALPPCHTLYQFYVNDGKLSLQLYQRSADIFLGVPFNIASYALLTHLVAHECGLEVGEFIHTFGDAHLYVNHLDQIKEQLSRTPRPAPTLQLNPDKHDIFDFDMKDIKLLNYDPYPAIKAPVAV
  
Inhibitor
Name:
BDBM50010239
Synonyms:
CHEMBL1236538
Type:
Small organic molecule
Emp. Form.:
C9H12ClN2O8P
Mol. Mass.:
342.627
SMILES:
O[C@H]1C[C@@H](O[C@@H]1COP(O)(O)=O)n1cc(Cl)c(=O)[nH]c1=O |r|
Structure:
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