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Target
Reverse transcriptase
Ligand
BDBM50479808
Substrate
n/a
Meas. Tech.
ChEMBL_541098 (CHEMBL1034081)
IC50
620±n/a nM
Citation
 Boojamra, CG; Parrish, JP; Sperandio, D; Gao, Y; Petrakovsky, OV; Lee, SK; Markevitch, DY; Vela, JE; Laflamme, G; Chen, JM; Ray, AS; Barron, AC; Sparacino, ML; Desai, MC; Kim, CU; Cihlar, T; Mackman, RL Design, synthesis, and anti-HIV activity of 4'-modified carbocyclic nucleoside phosphonate reverse transcriptase inhibitors. Bioorg Med Chem 17:1739-46 (2009) [PubMed]  Article 
Target
Name:
Reverse transcriptase
Synonyms:
n/a
Type:
Protein
Mol. Mass.:
29598.37
Organism:
Human immunodeficiency virus 1
Description:
Q9WKE8
Residue:
254
Sequence:
PISPITVPVKLKPGMDGPKVKQWPLTEEKIKALTEICTEMEKEGKIEKIGPENPYNTPVFAIKKKDSTKWRKVVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPLDKDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVIYQYMDDLYVGSDLEIEQHRAKIEELRQHLLRWGFTTPDKKHQKEPPFLWMGYELHPDKWTVQPIVLPEKDSWTVN
  
Inhibitor
Name:
BDBM50479808
Synonyms:
CHEMBL512522
Type:
Small organic molecule
Emp. Form.:
C13H18N5O10P3
Mol. Mass.:
497.2308
SMILES:
Nc1ncnc2n(cnc12)[C@@H]1C[C@@](OCP(O)(=O)OP(O)(=O)OP(O)(O)=O)(C=C)C=C1 |r,c:31|
Structure:
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