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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM50483840
Substrate
n/a
Meas. Tech.
ChEMBL_745707 (CHEMBL1776077)
IC50
143±n/a nM
Citation
 Chen, X; Yang, Y; Ma, B; Zhang, S; He, M; Gui, D; Hussain, S; Jing, C; Zhu, C; Yu, Q; Liu, Y Design and synthesis of potent and selective aldose reductase inhibitors based on pyridylthiadiazine scaffold. Eur J Med Chem 46:1536-44 (2011) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
ALDR_RAT | Akr1b1 | Akr1b4 | Aldose reductase | Aldr1
Type:
PROTEIN
Mol. Mass.:
35797.87
Organism:
Rattus norvegicus
Description:
ChEMBL_1512484
Residue:
316
Sequence:
MASHLELNNGTKMPTLGLGTWKSPPGQVTEAVKVAIDMGYRHIDCAQVYQNEKEVGVALQEKLKEQVVKRQDLFIVSKLWCTFHDQSMVKGACQKTLSDLQLDYLDLYLIHWPTGFKPGPDYFPLDASGNVIPSDTDFVDTWTAMEQLVDEGLVKAIGVSNFNPLQIERILNKPGLKYKPAVNQIECHPYLTQEKLIEYCHCKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKEIAAKYNKTTAQVLIRFPIQRNLVVIPKSVTPARIAENFKVFDFELSNEDMATLLSYNRNWRVCALMSCAKHKDYPFHAEV
  
Inhibitor
Name:
BDBM50483840
Synonyms:
CHEMBL1774248
Type:
Small organic molecule
Emp. Form.:
C16H16N4O6S
Mol. Mass.:
392.386
SMILES:
Cc1cnc2N(CC(O)=O)CN(Cc3cccc(c3)[N+]([O-])=O)S(=O)(=O)c2c1
Structure:
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