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Target
Endothelin-1 receptor
Ligand
BDBM50036289
Substrate
n/a
Meas. Tech.
ChEMBL_63361 (CHEMBL676097)
IC50
510±n/a nM
Citation
 Krystek, SR; Hunt, JT; Stein, PD; Stouch, TR Three-dimensional quantitative structure-activity relationships of sulfonamide endothelin inhibitors. J Med Chem 38:659-68 (1995) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
EDNRA_RAT | ENDOTHELIN A | Ednra | Endothelin receptor | Endothelin-1 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48256.91
Organism:
RAT
Description:
ENDOTHELIN A EDNRA RAT::P26684
Residue:
426
Sequence:
MGVLCFLASFWLALVGGAIADNAERYSANLSSHVEDFTPFPGTEFNFLGTTLQPPNLALPSNGSMHGYCPQQTKITTAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLITAIEIVSIWILSFILAIPEAIGFVMVPFEYKGEQHRTCMLNATTKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYDEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCHQSKSLMTSVPMNGTSIQWKNQEQNHNTERSSHKDSMN
  
Inhibitor
Name:
BDBM50036289
Synonyms:
4-Amino-N-(4-bromo-5-methyl-isoxazol-3-yl)-benzenesulfonamide | CHEMBL348641
Type:
Small organic molecule
Emp. Form.:
C10H10BrN3O3S
Mol. Mass.:
332.174
SMILES:
Cc1onc(NS(=O)(=O)c2ccc(N)cc2)c1Br
Structure:
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