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Target
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Ligand
BDBM50502328
Substrate
n/a
Meas. Tech.
ChEMBL_1806443 (CHEMBL4305802)
IC50
4440±n/a nM
Citation
 Tan, J; Grouleff, JJ; Jitkova, Y; Diaz, DB; Griffith, EC; Shao, W; Bogdanchikova, AF; Poda, G; Schimmer, AD; Lee, RE; Yudin, AK De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX. J Med Chem 62:6377-6390 (2019) [PubMed]  Article 
Target
Name:
ATP-dependent Clp protease proteolytic subunit, mitochondrial
Synonyms:
3.4.21.92 | ATP-dependent Clp protease proteolytic subunit, mitochondrial | CLPP | CLPP_HUMAN | Endopeptidase Clp
Type:
PROTEIN
Mol. Mass.:
30185.26
Organism:
Homo sapiens
Description:
ChEMBL_119055
Residue:
277
Sequence:
MWPGILVGGARVASCRYPALGPRLAAHFPAQRPPQRTLQNGLALQRCLHATATRALPLIPIVVEQTGRGERAYDIYSRLLRERIVCVMGPIDDSVASLVIAQLLFLQSESNKKPIHMYINSPGGVVTAGLAIYDTMQYILNPICTWCVGQAASMGSLLLAAGTPGMRHSLPNSRIMIHQPSGGARGQATDIAIQAEEIMKLKKQLYNIYAKHTKQSLQVIESAMERDRYMSPMEAQEFGILDKVLVHPPQDGEDEPTLVQKEPVEAAPAAEPVPAST
  
Inhibitor
Name:
BDBM50502328
Synonyms:
CHEMBL4472444
Type:
Small organic molecule
Emp. Form.:
C22H14N2O4
Mol. Mass.:
370.3576
SMILES:
O=C(Cc1coc2ccc3ccccc3c12)Oc1ccc(cc1)-c1nnco1
Structure:
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